5-Amino-1MQ (5-amino-1-methylquinolinium) is a small molecule — not a peptide — studied as a selective, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in NAD+ and methylation metabolism.

Is 5-Amino-1MQ a peptide?

No. It's a small-molecule chemical compound, often discussed alongside peptides like MOTS-c because both are studied in the metabolic-research category, but they are chemically and mechanistically distinct.

Is there human clinical evidence for 5-Amino-1MQ?

No. A 2024 review of the NNMT-inhibitor research field states directly that clinical trials focusing on NNMT have not been documented. All currently published data on 5-Amino-1MQ is preclinical. 5-Amino-1MQ is not an FDA-approved drug and is not a dietary supplement.

Research Library · Obsessed Living Research Team

5-Amino-1MQ: Research Overview, Mechanism & Published Studies

The Obsessed Living Research Team summarizes peer-reviewed peptide research for educational, research-use reference. Content is not medical advice. Our research standards.

References

Kraus D, et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity (Nature, 2014).
Neelakantan H, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice (Biochem Pharmacol, 2017).
Dimet-Wiley A, et al. Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice (Sci Rep, 2022).
Neelakantan H, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle (Biochem Pharmacol, 2019).
Sun WD, et al. Nicotinamide N-methyltransferase (NNMT): a novel therapeutic target for metabolic syndrome (Front Pharmacol, 2024, review).

Go Deeper

Related research

5-Amino-1MQ: Mechanism of Action in Published Studies
A research-framed look at how 5-Amino-1MQ inhibits NNMT and the downstream NAD+/SAM effects published studies have measured in adipose tissue, muscle, and the gut microbiome.
5-Amino-1MQ vs MOTS-c: What the Research Compares
5-Amino-1MQ and MOTS-c are frequently sold and searched together as metabolic research compounds, but published research studies them through two entirely different mechanisms.
5-Amino-1MQ Research FAQ
Common questions about 5-Amino-1MQ answered in a research context — what it is, what studies examine, and the limits of the evidence.

Research Materials

Related compounds

5-Amino-1MQ (5-Amino-1-Methylquinolinium)

1MQ

Compliance & Disclaimer

This product is supplied strictly for research purposes only. It is not intended for human or animal consumption and is not intended for therapeutic, dietary, cosmetic, diagnostic, or veterinary use.

Statements on this page have not been evaluated by the U.S. Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Human/animal consumption prohibited. Laboratory/in-vitro experimental use only.